hmmm... a couple of questions:
1) Are you a new user of PokerOffice, i.e. did you just download it? Or has it worked before and it recently stopped working?
2) Do you not get any error message or anything?
3. Can you please post the content of your system log here. Please read this on how to find the log:
I want to send my PokerOffice log file to support, where can I find it?