I have now scanned the complete PokerOffice program folder (c:\program files\pokeroffice\) with both Trend Micro Antivirus and F-secure Anti-Virus 2008 (using definition version 2008-02-08_02). Neither antivirus can find anything wrong with any file.
This raises a few questions; are you using the same (2008-02-08_02) definition file? If you are, have your version of pnthandler been infected by a virus?
My suggestion is that you try to install the latest patch:
www.pokeroffice.com/update.exe
Directly after the install make a virus scan and see if you get the same result as before. Also try to start PO and see if it works.
Even if you do not get a warning after updating and PO works the virus that infected your computer can still be present in the registry and in your system folder. So a complete virus scan clean up might be needed.
Again it would be very good if some people could send in the files to F-secure etc, both the file you get a varning for and if you do not get a warning for the file after you reinstalled maybe send that file too.
You can also send the infected file to us so we can compare it to our own original one.
I will keep monitoring this thread today and in the weekend to see what evolves.